Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats

The aim of this study was to evaluate the effect of β-caryophyllene on hypercholesterolemia using a model of hyperlipidemia induced by Triton WR-1339 in rats, as well as its possible effect on hepatic antioxidant enzymes. Thus, total cholesterol, triglycerides, low-density lipoprotein (LDL) choleste...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2017-02, Vol.390 (2), p.215-223
Hauptverfasser:	Baldissera, Matheus D., Souza, Carine F., Grando, Thirssa H., Doleski, Pedro H., Boligon, Aline A., Stefani, Lenita M., Monteiro, Silvia G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Biomarkers - blood Biomedical and Life Sciences Biomedicine Catalase - metabolism Disease Models, Animal Female Hydroxymethylglutaryl CoA Reductases - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypercholesterolemia - blood Hypercholesterolemia - chemically induced Hypercholesterolemia - drug therapy Lipids - blood Liver - drug effects Liver - metabolism Neurosciences Original Article Oxidative Stress - drug effects Pharmacology/Toxicology Polyethylene Glycols Rats, Wistar Reactive Oxygen Species - metabolism Sesquiterpenes - blood Sesquiterpenes - pharmacology Simvastatin - pharmacology Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism
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Zusammenfassung:	The aim of this study was to evaluate the effect of β-caryophyllene on hypercholesterolemia using a model of hyperlipidemia induced by Triton WR-1339 in rats, as well as its possible effect on hepatic antioxidant enzymes. Thus, total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were measured in serum, while reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), hepatic 3-hydroxy-3-methylglutayl coenzyme A (HMG-CoA) reductase, superoxide dismutase (SOD), and catalase (CAT) activities were measured in the hepatic tissue. In addition, seric concentrations of β-caryophyllene were measured to perform correlation studies. Serum samples from hypercholesterolemic rats show higher ( p
ISSN:	0028-1298 1432-1912
DOI:	10.1007/s00210-016-1326-3