Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

Highlights • LPS and ATP trigger NLRP3 inflammasome activation in vascular endothelial cells. • SIRT1 regulates NLRP3 inflammasome activation in vascular endothelial cells. • CD40 promotes NLRP3 inflammasome activation in vascular endothelial cells. • The effect of SIRT1 on NLRP3 inflammasome is par...

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Veröffentlicht in:	Immunobiology (1979) 2017-03, Vol.222 (3), p.552-561
Hauptverfasser:	Li, Yanxiang, Yang, Xiaofeng, He, Yanhao, Wang, Weirong, Zhang, Jiye, Zhang, Wei, Jing, Ting, Wang, Bo, Lin, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Advanced Basic Science Allergy and Immunology Animals CD40 Antigens - genetics CD40 Antigens - metabolism CD40 Ligand - genetics CD40 Ligand - metabolism Cytokines - blood Cytokines - metabolism Endothelial cells Endothelial Cells - metabolism Gene Expression Regulation Gene Knockdown Techniques Human Umbilical Vein Endothelial Cells Humans Inflammasomes - metabolism Inflammation Lipopolysaccharides - immunology Macrophages - immunology Macrophages - metabolism Male Models, Biological NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Rabbits Signal Transduction SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism
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Zusammenfassung:	Highlights • LPS and ATP trigger NLRP3 inflammasome activation in vascular endothelial cells. • SIRT1 regulates NLRP3 inflammasome activation in vascular endothelial cells. • CD40 promotes NLRP3 inflammasome activation in vascular endothelial cells. • The effect of SIRT1 on NLRP3 inflammasome is partly mediated by CD40. • Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2016.11.002