Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer

•Chitosan modified PLGA-nanoparticles of 5-fluorouracil (5-FU) were developed.•Formation of nanoparticles was confirmed by physicochemical characterization.•Optimized nanoparticles presented significant release of 5-FU.•Optimized nanoparticles of 5-FU also showed significant anticancer activity. 5-F...

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Veröffentlicht in:	International journal of biological macromolecules 2017-02, Vol.95, p.643-649
Hauptverfasser:	Badran, Mohamed M., Mady, Mohsen M., Ghannam, Magdy M., Shakeel, Faiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Chitosan - chemistry Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cytotoxicity Drug Liberation Fluorouracil - chemistry Fluorouracil - pharmacology Fluorouracil - therapeutic use HT29 Cells Humans Kinetics Nanoparticles Nanoparticles - chemistry Particle Size Polyesters - chemistry Polyglycolic Acid - chemistry Surface Properties
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