Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer

•Chitosan modified PLGA-nanoparticles of 5-fluorouracil (5-FU) were developed.•Formation of nanoparticles was confirmed by physicochemical characterization.•Optimized nanoparticles presented significant release of 5-FU.•Optimized nanoparticles of 5-FU also showed significant anticancer activity. 5-F...

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Veröffentlicht in:	International journal of biological macromolecules 2017-02, Vol.95, p.643-649
Hauptverfasser:	Badran, Mohamed M., Mady, Mohsen M., Ghannam, Magdy M., Shakeel, Faiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Chitosan - chemistry Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cytotoxicity Drug Liberation Fluorouracil - chemistry Fluorouracil - pharmacology Fluorouracil - therapeutic use HT29 Cells Humans Kinetics Nanoparticles Nanoparticles - chemistry Particle Size Polyesters - chemistry Polyglycolic Acid - chemistry Surface Properties
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Zusammenfassung:	•Chitosan modified PLGA-nanoparticles of 5-fluorouracil (5-FU) were developed.•Formation of nanoparticles was confirmed by physicochemical characterization.•Optimized nanoparticles presented significant release of 5-FU.•Optimized nanoparticles of 5-FU also showed significant anticancer activity. 5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLGA) nanoparticles [NPs] (C-5-FU PLGA NPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1–302.2nm with polydispersity index (PDI) of
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2016.11.098