Development and Evaluation of Capsule of Sodium Diclofenac and Paracetamol Using Mesocarp Babassu Powder as Excipient - Part II

The capsules are pharmaceutical forms extremely versatile used to administer drugs orally, thus demonstrating the relevance of search for new excipients. Therefore, it was aimed to demonstrate the technological feasibility of babassu mesocarp powder (MB) as an excipient in development of diclofenac capsules 50mg and paracetamol 500 mg. Two lots of capsule were produced for each active ingredient separately using MB and microcrystalline cellulose (MC) as an excipient. The analytical results of quality control of all lots remained within the limits accepted by the Brazilian Pharmacopoeia. Although the values of dissolution time coming from lots of CM and MB, the statistical analysis revealed that lots manufactured with MB showed a profile of release superior to CM, demonstrating the potential of MB as an excipient once the lots produced with MB showed a disintegration and dissolution equivalent to those obtained with CM lots.