Detection of the diuretic hydrochlorothiazide in a doping control urine sample as the result of a non-steroidal anti-inflammatory drug (NSAID) tablet contamination

Highlights • Contaminated medications can lead to positive doping controls. • Medications produced under GMP guidelines may lead to positive doping controls. • Diuretics ingested in micrograms are detectable in urine. • Reporting “specified” doping substances below a certain level is inappropriate....

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Veröffentlicht in:	Forensic science international 2016-10, Vol.267, p.166-172
Hauptverfasser:	Helmlin, Hans-Jörg, Mürner, André, Steiner, Samuel, Kamber, Matthias, Weber, Christina, Geyer, Hans, Guddat, Sven, Schänzer, Wilhelm, Thevis, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - urine Chromatography, Liquid Contamination Dietary supplements Diuretics Diuretics - analysis Doping Doping in Sports Drug Contamination Drugs Forensic sciences Good Manufacturing Practice Humans Hydrochlorothiazide Hydrochlorothiazide - analysis Ingestion Laboratories Male Mass spectrometry Mathematical analysis Pathology Pharmaceutical industry Sport Tablets Tandem Mass Spectrometry Urine Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Contaminated medications can lead to positive doping controls. • Medications produced under GMP guidelines may lead to positive doping controls. • Diuretics ingested in micrograms are detectable in urine. • Reporting “specified” doping substances below a certain level is inappropriate.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2016.08.029