A highly enantioselective synthesis of (R)-salmeterol using a chiral auxiliary

A highly enantioselective synthesis of (R)-salmeterol using a chiral auxiliary

A facile strategy for enantioselective synthesis of (R)-salmeterol is described via a chiral auxiliary starting from 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone through four or five steps. The product was obtained in good purity, enantiomeric excess and yield.

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Veröffentlicht in:Journal of chemical research 2016-09, Vol.40 (9), p.564-566
Hauptverfasser: Jiang, Lijue, Lin, Chenggang, Qiu, Yinhua, Quan, Xu, Zhu, Jing, Shi, Haijian
Format: Artikel
Sprache:eng
Schlagworte:
Purity
Strategy
Synthesis
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Zusammenfassung:A facile strategy for enantioselective synthesis of (R)-salmeterol is described via a chiral auxiliary starting from 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone through four or five steps. The product was obtained in good purity, enantiomeric excess and yield.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751916X14719559894647