Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid

Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid

A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantioselectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valua...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (76), p.11426-11429
Hauptverfasser: Bao, Xiaoze, Wei, Shiqiang, Zou, Liwei, He, Yuli, Xue, Fuzhao, Qu, Jingping, Wang, Baomin
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Asymmetry
Carbon
Catalysts
Chlorination
Pyrazolones
Transformations
Utilities
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Zusammenfassung:A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantioselectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc06236a