Diastereoselective and One-Pot Synthesis of Highly Substituted Cyclohexenones Using Claisen–Schmidt Condensation and Michael Addition

Diastereoselective and One-Pot Synthesis of Highly Substituted Cyclohexenones Using Claisen–Schmidt Condensation and Michael Addition

A high efficient and convenient one-pot three-component diastreoselective synthesis of polysubstituted cyclohexenones in excellent yields has been developed through Michael addition and Claisen-Schmidt condensation of aldehydes and acetophenone with 3-oxo-N-phenylbutanamide using piperidine as an ef...

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Veröffentlicht in:Journal of chemical research 2015-09, Vol.39 (9), p.509-514
Hauptverfasser: Mousavi, Mir Rasul, Gharari, Hadigheh, Maghsoodlou, Malek Taher, Hazeri, Nourallah, Dastorani, Parvaneh, Soria-Martínez, Ruben, García-Granda, Santiago
Format: Artikel
Sprache:eng
Schlagworte:
Acetophenone
Activation
Condensation
Piperidine
Reaction time
Reagents
Synthesis
Synthesis (chemistry)
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Beschreibung
Zusammenfassung:A high efficient and convenient one-pot three-component diastreoselective synthesis of polysubstituted cyclohexenones in excellent yields has been developed through Michael addition and Claisen-Schmidt condensation of aldehydes and acetophenone with 3-oxo-N-phenylbutanamide using piperidine as an effective reagent under mild conditions within sort reaction time without using any previous activation.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751915X14396601175593