A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde i...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-09, Vol.52 (75), p.11247-1125
Hauptverfasser: Lee, Yun Hak, Tang, Yonghe, Verwilst, Peter, Lin, Weiying, Kim, Jong Seung
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biotin
Biotin - chemistry
Cell Line, Tumor
Excitation
Fluorescent Dyes - chemistry
Formaldehyde
Formaldehyde - analysis
Formaldehyde - chemistry
Humans
Imaging, Three-Dimensional
Mice
Microscopy, Confocal
Neoplasms - chemistry
Neoplasms - metabolism
Neoplasms - pathology
NIH 3T3 Cells
Optical Imaging
Photons
Receptors
Sensors
Spectrometry, Fluorescence
Tumors
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Beschreibung
Zusammenfassung:A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth. A biotin appended formaldehyde sensor was found to visualise exogenous and endogenous formaldehyde levels in living cells and tumour tissues.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc06158c