Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720

A novel and efficient method for the selective monobenzoylation of N -Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc) 2 and Cs 2 CO 3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (44), p.23131-23136
Hauptverfasser: Hikawa, Hidemasa, Hamada, Maiko, Yokoyama, Yuusaku, Azumaya, Isao
Format: Artikel
Sprache:eng
Schlagworte:
Biomimetics
Phosphates
Reagents
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Zusammenfassung:A novel and efficient method for the selective monobenzoylation of N -Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc) 2 and Cs 2 CO 3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA02401J