Physical exercise for late-life major depression

Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression). A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.