Achiral Inorganic Gypsum Acts as an Origin of Chirality through Its Enantiotopic Surface in Conjunction with Asymmetric Autocatalysis

Achiral inorganic gypsum (CaSO4⋅2 H2O) triggers the asymmetric autocatalysis of pyrimidyl alkanol on its two‐dimensional enantiotopic faces to give highly enantioenriched alkanol products with absolute configurations corresponding to the respective enantiotopic surfaces. This is the first example of highly enantioselective synthesis on the enantiotopic surface of an achiral mineral. At face value: Achiral inorganic gypsum (CaSO4⋅2 H2O) triggers the asymmetric autocatalysis of pyrimidyl alkanol on its two‐dimensional enantiotopic faces to give highly enantioenriched alkanol products with absolute configurations corresponding to the respective enantiotopic surfaces. This is the first example of highly enantioselective synthesis on the enantiotopic surface of an achiral mineral.