Inflammatory Mediators and Pain in the First Year After Acute Episode of Low-Back Pain in Elderly Women: Longitudinal Data from Back Complaints in the Elders—Brazil

OBJECTIVEThe aims of this study were to determine the course of plasma levels of inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor α [TNF-α], soluble TNF receptor 1 [sTNF-R1]) and the severity of low-back pain (LBP) over 6 to 12 months after an acute episode of LBP in elderly women...

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Veröffentlicht in:American journal of physical medicine & rehabilitation 2017-08, Vol.96 (8), p.535-540
Hauptverfasser: Queiroz, Bárbara Zille, Pereira, Daniele Sirineu, Rosa, Nayza Maciel de Britto, Lopes, Renata Antunes, Andrade, André Gustavo Pereira, Felício, Diogo Carvalho, Jardim, Renata Muniz Freire Vinhal Siqueira, Leopoldino, Amanda Aparecida Oliveira, Silva, Juscélio Pereira, Pereira, Leani Souza Máximo
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Sprache:eng
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Zusammenfassung:OBJECTIVEThe aims of this study were to determine the course of plasma levels of inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor α [TNF-α], soluble TNF receptor 1 [sTNF-R1]) and the severity of low-back pain (LBP) over 6 to 12 months after an acute episode of LBP in elderly women and to establish an association between inflammatory mediators and LBP recovery. DESIGNThis was a longitudinal study of a subsample (155 elderly women with acute LBP, aged ≥65 years) of the international Back Complaints in the Elders cohort study. Plasma levels of IL-6, TNF-α, and sTNF-R1 were measured using enzyme-linked immunosorbent assays and pain severity using the numerical pain scale. RESULTSThere was a decrease in the severity of LBP (P = 0.033) and in the levels of IL-6 and TNF-α (P < 0.001) and an increase in sTNF-R1 (P < 0.001) in the first year after an acute episode of LBP. The probability of occurrence of pain relief at the 12-month follow-up was 2.22 times higher in elderly women who had low levels of IL-6 (
ISSN:0894-9115
1537-7385
DOI:10.1097/PHM.0000000000000661