Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin

Both dimethylarsinic acid (DMA(V)) and dimethylarsinous acid (DMA(III)) release iron from human liver ferritin (HLF) with or without the presence of ascorbic acid. With ascorbic acid the rate of iron release from HLF by DMA(V) was intermediate (3.37 nM/min, P

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Bibliographische Detailangaben
Veröffentlicht in:	Toxicology letters 2002-07, Vol.133 (1), p.47-57
Hauptverfasser:	Ahmad, Sarfaraz, Kitchin, Kirk T, Cullen, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic Ascorbic Acid - toxicity Cacodylic Acid - toxicity Dimethylarsinous acid, DMA(III) DNA damage DNA Damage - drug effects DNA, Superhelical - drug effects Drug Synergism Ferritins - drug effects Ferritins - metabolism Herbicides - toxicity Human liver ferritin Humans Iron Iron - metabolism Iron Chelating Agents - therapeutic use Liver - drug effects Liver - metabolism Pentetic Acid - therapeutic use Reactive oxygen species Reactive Oxygen Species - metabolism
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Beschreibung
Zusammenfassung:	Both dimethylarsinic acid (DMA(V)) and dimethylarsinous acid (DMA(III)) release iron from human liver ferritin (HLF) with or without the presence of ascorbic acid. With ascorbic acid the rate of iron release from HLF by DMA(V) was intermediate (3.37 nM/min, P
ISSN:	0378-4274 1879-3169
DOI:	10.1016/S0378-4274(02)00079-6