Pharmacokinetic Interactions of Nevirapine and Methadone and Guidelines for Use of Nevirapine to Treat Injection Drug Users

Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.

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Veröffentlicht in:	Clinical infectious diseases 2001-11, Vol.33 (9), p.1595-1597
Hauptverfasser:	Clarke, Susan M., Mulcahy, Fiona M., Tjia, John, Reynolds, Helen E., Gibbons, Sara E., Barry, Michael G., Back, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretrovirals Antiviral agents Antivirals Biological and medical sciences Cytochromes Dosage Drug Antagonism Drug interactions Enzymes Female HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV/AIDS Humans Injections Male Medical sciences Methadone Methadone - administration & dosage Methadone - pharmacokinetics Middle Aged Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacokinetics Nevirapine - administration & dosage Nevirapine - pharmacokinetics Pharmacokinetics Pharmacology. Drug treatments Practice Guidelines as Topic Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - pharmacokinetics Substance Abuse, Intravenous - complications Substance Abuse, Intravenous - drug therapy Withdrawal symptoms
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Beschreibung
Zusammenfassung:	Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/322519