Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients

Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Foot (Edinburgh, Scotland) Scotland), 2016-12, Vol.29, p.42-44
Hauptverfasser:	Carvalhais, Virginia, Ruivães, Ema, Pina-Cabral, Luis Bernardo, Mesquita, Barbara, Oliveira, Flávio, Monteiro, Maria Céu, Criado, Maria Begoña
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Arterial ischemia Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - genetics eNOS Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Ischemia - genetics Lower Extremity - blood supply Male Middle Aged Nitric Oxide Synthase Type III - genetics Orthopedics Platelet glycoprotein Platelet Glycoprotein GPIb-IX Complex - genetics Podiatry Polymorphism, Genetic Polymorphisms Type 2 diabetes mellitus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	44
container_issue
container_start_page	42
container_title	Foot (Edinburgh, Scotland)
container_volume	29
creator	Carvalhais, Virginia Ruivães, Ema Pina-Cabral, Luis Bernardo Mesquita, Barbara Oliveira, Flávio Monteiro, Maria Céu Criado, Maria Begoña
description	Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus;. • Podiatry may be complemented with laboratory risk markers.
doi_str_mv	10.1016/j.foot.2016.10.002
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1844354280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0958259216300955</els_id><sourcerecordid>1844354280</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-ba8bb597b56658a437d739122bce28605272f2c212f29f0c25e3370a0588b4353</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEokvhBTggH7lkscfrxJEQEqr4U6mih8LZcpxJ68WJg-1stU_Dq2KzhQMHLvZo_M3PM_5cVS8Z3TLKmjf77eh92kKOc2JLKTyqNkxwqKFr-ONqQzshaxAdnFXPYtxTSgUAPK3OoJVSth3bVD8v59GtOBskfiS3OGOyhhx0sDpZP0diZ7I4ndBhIrfuaPwSfEKbT_Q8EPxyfVMk6Q7JgAd0fplwToWlQ8JMccRGc6dxsrpknb_HQJyd-t_odFyQABms7jFhJBM6Z9MayZKvz6D4vHoyahfxxcN-Xn37-OHrxef66vrT5cX7q9pwaFLda9n3omt70TRC6h1vh5Z3DKA3CLLJc7cwggGW126kBgRy3lJNhZT9jgt-Xr0-cfN4P1aMSU2579yNntGvUTG5y7IdSJqlcJKa4GMMOKol2EmHo2JUFWPUXhVjVDGm5LIxuejVA3_tJxz-lvxxIgvengSYpzxYDCoaW3wZbECT1ODt__nv_ik3zs7WaPcdjxj3fg1zfj_FVARF1U35GuVnsIbTHAv-C0Gjtf8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844354280</pqid></control><display><type>article</type><title>Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Carvalhais, Virginia ; Ruivães, Ema ; Pina-Cabral, Luis Bernardo ; Mesquita, Barbara ; Oliveira, Flávio ; Monteiro, Maria Céu ; Criado, Maria Begoña</creator><creatorcontrib>Carvalhais, Virginia ; Ruivães, Ema ; Pina-Cabral, Luis Bernardo ; Mesquita, Barbara ; Oliveira, Flávio ; Monteiro, Maria Céu ; Criado, Maria Begoña</creatorcontrib><description>Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus;. • Podiatry may be complemented with laboratory risk markers.</description><identifier>ISSN: 0958-2592</identifier><identifier>EISSN: 1532-2963</identifier><identifier>DOI: 10.1016/j.foot.2016.10.002</identifier><identifier>PMID: 27888791</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Arterial ischemia ; Diabetes Mellitus, Type 2 - complications ; Diabetic Angiopathies - genetics ; eNOS ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Ischemia - genetics ; Lower Extremity - blood supply ; Male ; Middle Aged ; Nitric Oxide Synthase Type III - genetics ; Orthopedics ; Platelet glycoprotein ; Platelet Glycoprotein GPIb-IX Complex - genetics ; Podiatry ; Polymorphism, Genetic ; Polymorphisms ; Type 2 diabetes mellitus</subject><ispartof>Foot (Edinburgh, Scotland), 2016-12, Vol.29, p.42-44</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-ba8bb597b56658a437d739122bce28605272f2c212f29f0c25e3370a0588b4353</citedby><cites>FETCH-LOGICAL-c326t-ba8bb597b56658a437d739122bce28605272f2c212f29f0c25e3370a0588b4353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foot.2016.10.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27888791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalhais, Virginia</creatorcontrib><creatorcontrib>Ruivães, Ema</creatorcontrib><creatorcontrib>Pina-Cabral, Luis Bernardo</creatorcontrib><creatorcontrib>Mesquita, Barbara</creatorcontrib><creatorcontrib>Oliveira, Flávio</creatorcontrib><creatorcontrib>Monteiro, Maria Céu</creatorcontrib><creatorcontrib>Criado, Maria Begoña</creatorcontrib><title>Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients</title><title>Foot (Edinburgh, Scotland)</title><addtitle>Foot (Edinb)</addtitle><description>Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus;. • Podiatry may be complemented with laboratory risk markers.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arterial ischemia</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Angiopathies - genetics</subject><subject>eNOS</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Ischemia - genetics</subject><subject>Lower Extremity - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Orthopedics</subject><subject>Platelet glycoprotein</subject><subject>Platelet Glycoprotein GPIb-IX Complex - genetics</subject><subject>Podiatry</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphisms</subject><subject>Type 2 diabetes mellitus</subject><issn>0958-2592</issn><issn>1532-2963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks9u1DAQxiMEokvhBTggH7lkscfrxJEQEqr4U6mih8LZcpxJ68WJg-1stU_Dq2KzhQMHLvZo_M3PM_5cVS8Z3TLKmjf77eh92kKOc2JLKTyqNkxwqKFr-ONqQzshaxAdnFXPYtxTSgUAPK3OoJVSth3bVD8v59GtOBskfiS3OGOyhhx0sDpZP0diZ7I4ndBhIrfuaPwSfEKbT_Q8EPxyfVMk6Q7JgAd0fplwToWlQ8JMccRGc6dxsrpknb_HQJyd-t_odFyQABms7jFhJBM6Z9MayZKvz6D4vHoyahfxxcN-Xn37-OHrxef66vrT5cX7q9pwaFLda9n3omt70TRC6h1vh5Z3DKA3CLLJc7cwggGW126kBgRy3lJNhZT9jgt-Xr0-cfN4P1aMSU2579yNntGvUTG5y7IdSJqlcJKa4GMMOKol2EmHo2JUFWPUXhVjVDGm5LIxuejVA3_tJxz-lvxxIgvengSYpzxYDCoaW3wZbECT1ODt__nv_ik3zs7WaPcdjxj3fg1zfj_FVARF1U35GuVnsIbTHAv-C0Gjtf8</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Carvalhais, Virginia</creator><creator>Ruivães, Ema</creator><creator>Pina-Cabral, Luis Bernardo</creator><creator>Mesquita, Barbara</creator><creator>Oliveira, Flávio</creator><creator>Monteiro, Maria Céu</creator><creator>Criado, Maria Begoña</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients</title><author>Carvalhais, Virginia ; Ruivães, Ema ; Pina-Cabral, Luis Bernardo ; Mesquita, Barbara ; Oliveira, Flávio ; Monteiro, Maria Céu ; Criado, Maria Begoña</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-ba8bb597b56658a437d739122bce28605272f2c212f29f0c25e3370a0588b4353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arterial ischemia</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Angiopathies - genetics</topic><topic>eNOS</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Ischemia - genetics</topic><topic>Lower Extremity - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Orthopedics</topic><topic>Platelet glycoprotein</topic><topic>Platelet Glycoprotein GPIb-IX Complex - genetics</topic><topic>Podiatry</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphisms</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalhais, Virginia</creatorcontrib><creatorcontrib>Ruivães, Ema</creatorcontrib><creatorcontrib>Pina-Cabral, Luis Bernardo</creatorcontrib><creatorcontrib>Mesquita, Barbara</creatorcontrib><creatorcontrib>Oliveira, Flávio</creatorcontrib><creatorcontrib>Monteiro, Maria Céu</creatorcontrib><creatorcontrib>Criado, Maria Begoña</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Foot (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalhais, Virginia</au><au>Ruivães, Ema</au><au>Pina-Cabral, Luis Bernardo</au><au>Mesquita, Barbara</au><au>Oliveira, Flávio</au><au>Monteiro, Maria Céu</au><au>Criado, Maria Begoña</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients</atitle><jtitle>Foot (Edinburgh, Scotland)</jtitle><addtitle>Foot (Edinb)</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>29</volume><spage>42</spage><epage>44</epage><pages>42-44</pages><issn>0958-2592</issn><eissn>1532-2963</eissn><abstract>Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus;. • Podiatry may be complemented with laboratory risk markers.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>27888791</pmid><doi>10.1016/j.foot.2016.10.002</doi><tpages>3</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0958-2592
ispartof	Foot (Edinburgh, Scotland), 2016-12, Vol.29, p.42-44
issn	0958-2592 1532-2963
language	eng
recordid	cdi_proquest_miscellaneous_1844354280
source	MEDLINE; Access via ScienceDirect (Elsevier)
subjects	Aged Aged, 80 and over Arterial ischemia Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - genetics eNOS Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Ischemia - genetics Lower Extremity - blood supply Male Middle Aged Nitric Oxide Synthase Type III - genetics Orthopedics Platelet glycoprotein Platelet Glycoprotein GPIb-IX Complex - genetics Podiatry Polymorphism, Genetic Polymorphisms Type 2 diabetes mellitus
title	Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T04%3A19%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20genetic%20variations%20in%20platelet%20glycoproteins%20and%20eNOS%20in%20the%20development%20of%20arterial%20ischaemia%20of%20lower%20limbs%20in%20type%202%20diabetes%20mellitus%20patients&rft.jtitle=Foot%20(Edinburgh,%20Scotland)&rft.au=Carvalhais,%20Virginia&rft.date=2016-12-01&rft.volume=29&rft.spage=42&rft.epage=44&rft.pages=42-44&rft.issn=0958-2592&rft.eissn=1532-2963&rft_id=info:doi/10.1016/j.foot.2016.10.002&rft_dat=%3Cproquest_cross%3E1844354280%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1844354280&rft_id=info:pmid/27888791&rft_els_id=S0958259216300955&rfr_iscdi=true