Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients

Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes...

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Veröffentlicht in:	Foot (Edinburgh, Scotland) Scotland), 2016-12, Vol.29, p.42-44
Hauptverfasser:	Carvalhais, Virginia, Ruivães, Ema, Pina-Cabral, Luis Bernardo, Mesquita, Barbara, Oliveira, Flávio, Monteiro, Maria Céu, Criado, Maria Begoña
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Arterial ischemia Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - genetics eNOS Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Ischemia - genetics Lower Extremity - blood supply Male Middle Aged Nitric Oxide Synthase Type III - genetics Orthopedics Platelet glycoprotein Platelet Glycoprotein GPIb-IX Complex - genetics Podiatry Polymorphism, Genetic Polymorphisms Type 2 diabetes mellitus
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Beschreibung
Zusammenfassung:	Highlights • Arterial ischaemia of lower limbs is prevalent in diabetes mellitus;. • Ischaemia genetic predisposition was assessed in type 2 diabetes mellitus;. • The −5CC genotype in Kozak sequence of GPIbα was link to a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus;. • Podiatry may be complemented with laboratory risk markers.
ISSN:	0958-2592 1532-2963
DOI:	10.1016/j.foot.2016.10.002