Time course of organ of Corti degeneration after noise exposure

From our permanent collection of plastic-embedded flat preparations of chinchilla cochleae, 22 controls and 199 ears from noise-exposed animals were used to determine when, postexposure, hair cell (HC) and supporting cell (SC) degeneration were completed. The exposed ears were divided into four grou...

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Veröffentlicht in:	Hearing research 2017-02, Vol.344, p.158-169
Hauptverfasser:	Bohne, Barbara A., Kimlinger, Melissa, Harding, Gary W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Cell Death Chinchilla Disease Models, Animal Hair Cells, Auditory, Inner - pathology Hair Cells, Auditory, Outer - pathology Hearing Loss, Noise-Induced - etiology Hearing Loss, Noise-Induced - pathology Labyrinth Supporting Cells - pathology Nerve Degeneration Noise Noise - adverse effects Organ of Corti Organ of Corti - pathology Postexposure degeneration Quantification of damage Time Factors
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Zusammenfassung:	From our permanent collection of plastic-embedded flat preparations of chinchilla cochleae, 22 controls and 199 ears from noise-exposed animals were used to determine when, postexposure, hair cell (HC) and supporting cell (SC) degeneration were completed. The exposed ears were divided into four groups based on exposure parameters: 0.5- or 4-kHz octave band of noise at moderate (M) or high (H) intensities. Postexposure survival ranged from
ISSN:	0378-5955 1878-5891
DOI:	10.1016/j.heares.2016.11.009