Sae regulator factor impairs the response to photodynamic inactivation mediated by Toluidine blue in Staphylococcus aureus

Highlights • Sae , a virulence regulator of S. aureus protected the bacteria against photoinactivation. • The protective effect of sae was absent in biofilm growing bacteria. • RsbU, mgrA or agr , regulators related to stress response, did not modify the treatment.

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Bibliographische Detailangaben
Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2016-12, Vol.16, p.136-141
Hauptverfasser:	Gándara, Lautaro, Mamone, Leandro, Dotto, Cristian, Buzzola, Fernanda, Casas, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Biofilms - drug effects Biofilms - growth & development Cell Survival - drug effects Cell Survival - physiology Disinfection - methods Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Hematology, Oncology and Palliative Medicine Humans Internal Medicine Light Photochemotherapy - methods Photodynamic inactivation Photosensitizing Agents - administration & dosage Sae Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus aureus - radiation effects Toliudine blue Tolonium Chloride - administration & dosage Virulence Factors - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Sae , a virulence regulator of S. aureus protected the bacteria against photoinactivation. • The protective effect of sae was absent in biofilm growing bacteria. • RsbU, mgrA or agr , regulators related to stress response, did not modify the treatment.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2016.09.005