Role of inflammation in obesity-related breast cancer

Highlights • Obesity is associated with chronic inflammation. • Obesity and inflammation correlate with risk and progression in breast cancer. • Inflammation impacts obesity-related breast cancer at systemic and local levels. • Macrophages are crucial for promoting inflammation in obesity-related br...

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Veröffentlicht in:	Current opinion in pharmacology 2016-12, Vol.31, p.114-122
Hauptverfasser:	Crespi, Elisa, Bottai, Giulia, Santarpia, Libero
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - drug therapy Breast Neoplasms - etiology Breast Neoplasms - pathology Chronic Disease Disease Progression Drug Design Estrogens - metabolism Female Humans Inflammation - complications Inflammation - etiology Inflammation - pathology Inflammation Mediators - metabolism Internal Medicine Macrophages - metabolism Medical Education Obesity - complications Receptors, Progesterone - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights • Obesity is associated with chronic inflammation. • Obesity and inflammation correlate with risk and progression in breast cancer. • Inflammation impacts obesity-related breast cancer at systemic and local levels. • Macrophages are crucial for promoting inflammation in obesity-related breast cancer. • Targeting inflammation may have relevant therapeutic implications for breast cancer.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.11.004