Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy
Highlights • Isomers of Zn-porphyrins were compared for uptake and antibacterial photo-efficiency. • Shifting substituents from ortho to meta position increased the photo-efficiency. • A meta hexyl derivative displayed the highest antibacterial effect. • Bactericidal activity depends on shape of mol...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2017-03, Vol.17, p.154-159 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | Alenezi, Khazna Tovmasyan, Artak Batinic-Haberle, Ines Benov, Ludmil T |
| description | Highlights • Isomers of Zn-porphyrins were compared for uptake and antibacterial photo-efficiency. • Shifting substituents from ortho to meta position increased the photo-efficiency. • A meta hexyl derivative displayed the highest antibacterial effect. • Bactericidal activity depends on shape of molecule and position of charges. |
| doi_str_mv | 10.1016/j.pdpdt.2016.11.009 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Photodiagnosis and photodynamic therapy, 2017-03, Vol.17, p.154-159 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antimicrobial photodynamic therapy Bacteriological Techniques Cationic Zn-porphyrin Escherichia coli Escherichia coli - drug effects Gram-negative Hematology, Oncology and Palliative Medicine Humans Internal Medicine Metalloporphyrins - chemistry Metalloporphyrins - pharmacology Photochemotherapy - methods Photosensitizer Photosensitizing Agents - pharmacology Zinc - pharmacology |
| title | Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy |
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