Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy

Highlights • Isomers of Zn-porphyrins were compared for uptake and antibacterial photo-efficiency. • Shifting substituents from ortho to meta position increased the photo-efficiency. • A meta hexyl derivative displayed the highest antibacterial effect. • Bactericidal activity depends on shape of mol...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2017-03, Vol.17, p.154-159
Hauptverfasser:	Alenezi, Khazna, Tovmasyan, Artak, Batinic-Haberle, Ines, Benov, Ludmil T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial photodynamic therapy Bacteriological Techniques Cationic Zn-porphyrin Escherichia coli Escherichia coli - drug effects Gram-negative Hematology, Oncology and Palliative Medicine Humans Internal Medicine Metalloporphyrins - chemistry Metalloporphyrins - pharmacology Photochemotherapy - methods Photosensitizer Photosensitizing Agents - pharmacology Zinc - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Isomers of Zn-porphyrins were compared for uptake and antibacterial photo-efficiency. • Shifting substituents from ortho to meta position increased the photo-efficiency. • A meta hexyl derivative displayed the highest antibacterial effect. • Bactericidal activity depends on shape of molecule and position of charges.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2016.11.009