Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats
Abstract Background Severe hemorrhage shock and resuscitation is a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia –reperfusion...
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| Veröffentlicht in: | The Journal of surgical research 2016-12, Vol.206 (2), p.307-315 |
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| description | Abstract Background Severe hemorrhage shock and resuscitation is a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia –reperfusion in rats. The aim of this study was to investigate whether sevoflurane postconditioning could improve spatial learning and memory ability after hemorrhage shock and resuscitation in rats. Methods Thirty-five male rats were randomized into five groups: sham group, shock group, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) and high concentration (sevo3, 3.6%) of sevoflurane postconditioning groups. The spatial learning and memory ability of rats was measured by Morris water maze (MWM) three days after the operation. The expression of choline acetyltransferase (CHAT) and acetylcholinesterase (ACHE) in the hippocampus CA1 region was observed by immunohistochemistry method after the MWM test. Results The ability of spatial learning and memory of rats and the expression of CHAT was significantly declined while the expression of ACHE increased in the shock group compared with the sham group ( P |
| doi_str_mv | 10.1016/j.jss.2016.08.026 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1844024616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0022480416302943</els_id><sourcerecordid>1844024616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-1f45b9597c1bd52f3fcee4c32637ceed74711d73d680646a87f7cc189e0490a3</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEotvCD-CCfOSS4K-NHSEhoQooUiWQ6N3y2pOu0yRePE7RXvnlON3CgQMnj61nXmueqapXjDaMsvbt0AyIDS9lQ3VDefuk2jDabWvdKvG02lDKeS01lWfVOeJAy71T4nl1xpXWUnC5qX59i5hdnH3IIc5hviU_Q94ThPvYj0uyMxA7wRhishmQ4MHmYEcygk0PtJ09mWCK6Ug89MGFTGyfIZH9-pj29hYI7qO7eyAT4IKFsetnJMykpOKL6llvR4SXj-dFdfPp483lVX399fOXyw_XtZNU55r1crvrtp1ybOe3vBe9A5BO8FaoUnklFWNeCd9q2srWatUr55jugMqOWnFRvTnFHlL8sQBmMwV0MI5lxrigYVpKymXL2oKyE-pSREzQm0MKk01Hw6hZzZvBFPNmNW-oNsV86Xn9GL_sJvB_O_6oLsC7EwBlxvsAyRQTMDvwIYHLxsfw3_j3_3S7MczB2fEOjoBDXNJc5BlmkBtqvq-rXzdfpilLl0L8BgTirD8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844024616</pqid></control><display><type>article</type><title>Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hu, Xianwen ; Wang, Jingxian ; Zhang, Qiquan ; Duan, Xiaowen ; Chen, Zhiwu ; Zhang, Ye</creator><creatorcontrib>Hu, Xianwen ; Wang, Jingxian ; Zhang, Qiquan ; Duan, Xiaowen ; Chen, Zhiwu ; Zhang, Ye</creatorcontrib><description>Abstract Background Severe hemorrhage shock and resuscitation is a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia –reperfusion in rats. The aim of this study was to investigate whether sevoflurane postconditioning could improve spatial learning and memory ability after hemorrhage shock and resuscitation in rats. Methods Thirty-five male rats were randomized into five groups: sham group, shock group, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) and high concentration (sevo3, 3.6%) of sevoflurane postconditioning groups. The spatial learning and memory ability of rats was measured by Morris water maze (MWM) three days after the operation. The expression of choline acetyltransferase (CHAT) and acetylcholinesterase (ACHE) in the hippocampus CA1 region was observed by immunohistochemistry method after the MWM test. Results The ability of spatial learning and memory of rats and the expression of CHAT was significantly declined while the expression of ACHE increased in the shock group compared with the sham group ( P <0.05). Sevoflurane postconditioning with the concentrations of 2.4% and 3.6% significantly ameliorated the spatial learning and memory ability and increased the expression of CHAT and decreased the expression of ACHE in hippocampal CA1 region when compared with shock group ( P <0.05). Conclusions Postconditioning with sevoflurane at the concentrations of 2.4% and 3.6% which improved the ability of spatial learning and memory after hemorrhage shock and resuscitation in rats may involve the protection of the cholinergic neurons in hippocampal CA1 region.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2016.08.026</identifier><identifier>PMID: 27884324</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetylcholinesterase ; Animals ; Biomarkers - metabolism ; Choline acetyltransferase ; Choline O-Acetyltransferase - metabolism ; Cholinergic Neurons - drug effects ; Cholinergic Neurons - metabolism ; Hemorrhage shock and resuscitation ; Hippocampus - blood supply ; Hippocampus - drug effects ; Hippocampus - metabolism ; Ischemic Postconditioning - methods ; Learning Disorders - etiology ; Learning Disorders - prevention & control ; Male ; Maze Learning - drug effects ; Memory Disorders - etiology ; Memory Disorders - prevention & control ; Methyl Ethers - pharmacology ; Methyl Ethers - therapeutic use ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - drug therapy ; Reperfusion Injury - etiology ; Resuscitation ; Sevoflurane postconditioning ; Shock, Hemorrhagic - complications ; Shock, Hemorrhagic - therapy ; Spatial Learning - drug effects ; Spatial learning and memory ; Surgery ; Treatment Outcome</subject><ispartof>The Journal of surgical research, 2016-12, Vol.206 (2), p.307-315</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-1f45b9597c1bd52f3fcee4c32637ceed74711d73d680646a87f7cc189e0490a3</citedby><cites>FETCH-LOGICAL-c408t-1f45b9597c1bd52f3fcee4c32637ceed74711d73d680646a87f7cc189e0490a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jss.2016.08.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27884324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Xianwen</creatorcontrib><creatorcontrib>Wang, Jingxian</creatorcontrib><creatorcontrib>Zhang, Qiquan</creatorcontrib><creatorcontrib>Duan, Xiaowen</creatorcontrib><creatorcontrib>Chen, Zhiwu</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><title>Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Abstract Background Severe hemorrhage shock and resuscitation is a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia –reperfusion in rats. The aim of this study was to investigate whether sevoflurane postconditioning could improve spatial learning and memory ability after hemorrhage shock and resuscitation in rats. Methods Thirty-five male rats were randomized into five groups: sham group, shock group, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) and high concentration (sevo3, 3.6%) of sevoflurane postconditioning groups. The spatial learning and memory ability of rats was measured by Morris water maze (MWM) three days after the operation. The expression of choline acetyltransferase (CHAT) and acetylcholinesterase (ACHE) in the hippocampus CA1 region was observed by immunohistochemistry method after the MWM test. Results The ability of spatial learning and memory of rats and the expression of CHAT was significantly declined while the expression of ACHE increased in the shock group compared with the sham group ( P <0.05). Sevoflurane postconditioning with the concentrations of 2.4% and 3.6% significantly ameliorated the spatial learning and memory ability and increased the expression of CHAT and decreased the expression of ACHE in hippocampal CA1 region when compared with shock group ( P <0.05). Conclusions Postconditioning with sevoflurane at the concentrations of 2.4% and 3.6% which improved the ability of spatial learning and memory after hemorrhage shock and resuscitation in rats may involve the protection of the cholinergic neurons in hippocampal CA1 region.</description><subject>Acetylcholinesterase</subject><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Choline acetyltransferase</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cholinergic Neurons - drug effects</subject><subject>Cholinergic Neurons - metabolism</subject><subject>Hemorrhage shock and resuscitation</subject><subject>Hippocampus - blood supply</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Ischemic Postconditioning - methods</subject><subject>Learning Disorders - etiology</subject><subject>Learning Disorders - prevention & control</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - prevention & control</subject><subject>Methyl Ethers - pharmacology</subject><subject>Methyl Ethers - therapeutic use</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Reperfusion Injury - etiology</subject><subject>Resuscitation</subject><subject>Sevoflurane postconditioning</subject><subject>Shock, Hemorrhagic - complications</subject><subject>Shock, Hemorrhagic - therapy</subject><subject>Spatial Learning - drug effects</subject><subject>Spatial learning and memory</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEotvCD-CCfOSS4K-NHSEhoQooUiWQ6N3y2pOu0yRePE7RXvnlON3CgQMnj61nXmueqapXjDaMsvbt0AyIDS9lQ3VDefuk2jDabWvdKvG02lDKeS01lWfVOeJAy71T4nl1xpXWUnC5qX59i5hdnH3IIc5hviU_Q94ThPvYj0uyMxA7wRhishmQ4MHmYEcygk0PtJ09mWCK6Ug89MGFTGyfIZH9-pj29hYI7qO7eyAT4IKFsetnJMykpOKL6llvR4SXj-dFdfPp483lVX399fOXyw_XtZNU55r1crvrtp1ybOe3vBe9A5BO8FaoUnklFWNeCd9q2srWatUr55jugMqOWnFRvTnFHlL8sQBmMwV0MI5lxrigYVpKymXL2oKyE-pSREzQm0MKk01Hw6hZzZvBFPNmNW-oNsV86Xn9GL_sJvB_O_6oLsC7EwBlxvsAyRQTMDvwIYHLxsfw3_j3_3S7MczB2fEOjoBDXNJc5BlmkBtqvq-rXzdfpilLl0L8BgTirD8</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Hu, Xianwen</creator><creator>Wang, Jingxian</creator><creator>Zhang, Qiquan</creator><creator>Duan, Xiaowen</creator><creator>Chen, Zhiwu</creator><creator>Zhang, Ye</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats</title><author>Hu, Xianwen ; Wang, Jingxian ; Zhang, Qiquan ; Duan, Xiaowen ; Chen, Zhiwu ; Zhang, Ye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-1f45b9597c1bd52f3fcee4c32637ceed74711d73d680646a87f7cc189e0490a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetylcholinesterase</topic><topic>Animals</topic><topic>Biomarkers - metabolism</topic><topic>Choline acetyltransferase</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cholinergic Neurons - drug effects</topic><topic>Cholinergic Neurons - metabolism</topic><topic>Hemorrhage shock and resuscitation</topic><topic>Hippocampus - blood supply</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Ischemic Postconditioning - methods</topic><topic>Learning Disorders - etiology</topic><topic>Learning Disorders - prevention & control</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - prevention & control</topic><topic>Methyl Ethers - pharmacology</topic><topic>Methyl Ethers - therapeutic use</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Reperfusion Injury - etiology</topic><topic>Resuscitation</topic><topic>Sevoflurane postconditioning</topic><topic>Shock, Hemorrhagic - complications</topic><topic>Shock, Hemorrhagic - therapy</topic><topic>Spatial Learning - drug effects</topic><topic>Spatial learning and memory</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Xianwen</creatorcontrib><creatorcontrib>Wang, Jingxian</creatorcontrib><creatorcontrib>Zhang, Qiquan</creatorcontrib><creatorcontrib>Duan, Xiaowen</creatorcontrib><creatorcontrib>Chen, Zhiwu</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Xianwen</au><au>Wang, Jingxian</au><au>Zhang, Qiquan</au><au>Duan, Xiaowen</au><au>Chen, Zhiwu</au><au>Zhang, Ye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>206</volume><issue>2</issue><spage>307</spage><epage>315</epage><pages>307-315</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Abstract Background Severe hemorrhage shock and resuscitation is a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia –reperfusion in rats. The aim of this study was to investigate whether sevoflurane postconditioning could improve spatial learning and memory ability after hemorrhage shock and resuscitation in rats. Methods Thirty-five male rats were randomized into five groups: sham group, shock group, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) and high concentration (sevo3, 3.6%) of sevoflurane postconditioning groups. The spatial learning and memory ability of rats was measured by Morris water maze (MWM) three days after the operation. The expression of choline acetyltransferase (CHAT) and acetylcholinesterase (ACHE) in the hippocampus CA1 region was observed by immunohistochemistry method after the MWM test. Results The ability of spatial learning and memory of rats and the expression of CHAT was significantly declined while the expression of ACHE increased in the shock group compared with the sham group ( P <0.05). Sevoflurane postconditioning with the concentrations of 2.4% and 3.6% significantly ameliorated the spatial learning and memory ability and increased the expression of CHAT and decreased the expression of ACHE in hippocampal CA1 region when compared with shock group ( P <0.05). Conclusions Postconditioning with sevoflurane at the concentrations of 2.4% and 3.6% which improved the ability of spatial learning and memory after hemorrhage shock and resuscitation in rats may involve the protection of the cholinergic neurons in hippocampal CA1 region.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27884324</pmid><doi>10.1016/j.jss.2016.08.026</doi><tpages>9</tpages></addata></record> |
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| subjects | Acetylcholinesterase Animals Biomarkers - metabolism Choline acetyltransferase Choline O-Acetyltransferase - metabolism Cholinergic Neurons - drug effects Cholinergic Neurons - metabolism Hemorrhage shock and resuscitation Hippocampus - blood supply Hippocampus - drug effects Hippocampus - metabolism Ischemic Postconditioning - methods Learning Disorders - etiology Learning Disorders - prevention & control Male Maze Learning - drug effects Memory Disorders - etiology Memory Disorders - prevention & control Methyl Ethers - pharmacology Methyl Ethers - therapeutic use Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - etiology Resuscitation Sevoflurane postconditioning Shock, Hemorrhagic - complications Shock, Hemorrhagic - therapy Spatial Learning - drug effects Spatial learning and memory Surgery Treatment Outcome |
| title | Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats |
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