Sex-specific association between functional neuropeptide S receptor gene ( NPSR1 ) variants and cortisol and central stress responses

Sex-specific association between functional neuropeptide S receptor gene ( NPSR1 ) variants and cortisol and central stress responses

Highlights • Two independent cohorts with n = 277 and n = 65 healthy females and males. • Two different stress paradigms (TSST and Scan STRESS ), with one being used in the MRI scanner. • Exploratory converging evidence from both substudies for the view that genetic variation in the neuropeptide S r...

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Veröffentlicht in:Psychoneuroendocrinology 2017-02, Vol.76, p.49-56
Hauptverfasser: Streit, Fabian, Akdeniz, Ceren, Haddad, Leila, Kumsta, Robert, Entringer, Sonja, Frank, Josef, Yim, Ilona S, Zänkert, Sandra, Witt, Stephanie H, Kirsch, Peter, Rietschel, Marcella, Wüst, Stefan
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Endocrinology & Metabolism
Female
Humans
Hydrocortisone - metabolism
Male
Polymorphism, Single Nucleotide
Psychiatry
Receptors, G-Protein-Coupled - genetics
Saliva - chemistry
Sex Factors
Stress, Psychological - genetics
Stress, Psychological - metabolism
Young Adult
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Zusammenfassung:Highlights • Two independent cohorts with n = 277 and n = 65 healthy females and males. • Two different stress paradigms (TSST and Scan STRESS ), with one being used in the MRI scanner. • Exploratory converging evidence from both substudies for the view that genetic variation in the neuropeptide S receptor gene modulates both cortisol responses to acute stress as well as neural stress processing in a sex-specific manner.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.10.027