Heritability estimates of muscle strength‐related phenotypes: A systematic review and meta‐analysis

The purpose of this study was to clarify the heritability estimates of human muscle strength‐related phenotypes (H2‐msp). A systematic literature search was conducted using PubMed (through August 22, 2016). Studies reporting the H2‐msp for healthy subjects in a sedentary state were included. Random‐effects models were used to calculate the weighted mean heritability estimates. Moreover, subgroup analyses were performed based on phenotypic categories (eg, grip strength, isotonic strength, jumping ability). Sensitivity analyses were also conducted to investigate potential sources of heterogeneity of H2‐msp, which included age and sex. Twenty‐four articles including 58 measurements were included in the meta‐analysis. The weighted mean H2‐msp for all 58 measurements was 0.52 (95% confidence intervals [CI]: 0.48–0.56), with high heterogeneity (I2=91.0%, P