Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-11, Vol.162 (1), p.51-55
Hauptverfasser:	Zhdanov, V. V., Miroshnichenko, L. A., Udut, E. V., Zyuz’kov, G. N., Khrichkova, T. Yu, Simanina, E. V., Sherstoboev, E. Yu, Stavrova, L. A., Agafonov, V. I., Chaikovskii, A. V., Minakova, M. Yu, Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adherent cells Anemia Anemia - genetics Anemia - metabolism Anemia - pathology Animals Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cell Biology Chromones - pharmacology Disease Models, Animal Erythropoiesis - drug effects Erythropoiesis - genetics Erythropoietin Erythropoietin - genetics Erythropoietin - metabolism Extracellular signal-regulated kinase Flavonoids - pharmacology Gene Expression Regulation Hemorrhage Hemorrhage - genetics Hemorrhage - metabolism Hemorrhage - pathology Imidazoles - pharmacology Internal Medicine Laboratory Medicine Male MAP kinase Metabolic pathways Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Morpholines - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Pathology Pharmacology and Toxicology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Signal Transduction
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Zusammenfassung:	The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3543-7