Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains

Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains

The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90-99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains of the human pathogen Staphylococcus aureus. The mate...

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Veröffentlicht in:Biotechnology letters 2002-05, Vol.24 (10), p.801-805
Hauptverfasser: JIAN LIN, TILLER, Joerg C, SANG BEOM LEE, LEWIS, Kim, KLIBANOV, Alexander M
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotic resistance
Applied microbiology
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Microbiology
Miscellaneous
Silica
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Zusammenfassung:The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90-99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains of the human pathogen Staphylococcus aureus. The material created was similarly lethal to strains expressing multidrug resistance pumps, the only known mechanism of resistance to cationic antiseptics.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1015584423358