Conserved hierarchical gain of chromosome 4 is an independent prognostic factor in high hyperdiploid pediatric acute lymphoblastic leukemia

Highlights • 8 chromosomes defined modal number by iFISH can prognostically stratify B-pALL. • Modal number of ≥ 55 relates significantly to better outcome of hyperdiploid B-pALL. • Hyperdiploid B-pALL with ≥ 55 chromosomes reveals less complex subclonal landscape. • Highly conserved chromosomal gai...

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Veröffentlicht in:	Leukemia research 2017-01, Vol.52, p.28-33
Hauptverfasser:	Vojcek, Á, Pajor, G, Alpár, D, Mátics, R, Pótó, L, Szuhai, K, Pajor, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Child, Preschool Chromosome Aberrations Chromosomes, Human, Pair 4 - genetics Diploidy Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Hyperdiploidy iFISH Infant Lymphoblastic leukemia Male Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Prognosis Survival Analysis Trisomy
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Zusammenfassung:	Highlights • 8 chromosomes defined modal number by iFISH can prognostically stratify B-pALL. • Modal number of ≥ 55 relates significantly to better outcome of hyperdiploid B-pALL. • Hyperdiploid B-pALL with ≥ 55 chromosomes reveals less complex subclonal landscape. • Highly conserved chromosomal gain is a unique feature of high hyperdiploid B-pALL. • Conserved hierarchical gain of chromosome 4 is an independent prognostic factor.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2016.11.007