Langerhans cell number is a strong and independent prognostic factor for head and neck squamous cell carcinomas

Highlights • High Langerhans cell number in stromal compartment is associated with longer RFS and OS. • Langerhans cell number is an independent prognostic factor for HNSCC patients. • Langerhans cell number increases in cancer lesions and invaded lymph nodes compared to preneoplastic lesions. • Num...

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Veröffentlicht in:	Oral oncology 2016-11, Vol.62, p.1-10
Hauptverfasser:	Kindt, Nadège, Descamps, Géraldine, Seminerio, Imelda, Bellier, Justine, Lechien, Jérôme R, Pottier, Charles, Larsimont, Denis, Journé, Fabrice, Delvenne, Philippe, Saussez, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphapapillomavirus - isolation & purification Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Hematology, Oncology and Palliative Medicine HNSCC HPV Humans Langerhans cell Langerhans Cells - pathology Multivariate analysis Otolaryngology Prognosis Squamous Cell Carcinoma of Head and Neck Survival Analysis
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Zusammenfassung:	Highlights • High Langerhans cell number in stromal compartment is associated with longer RFS and OS. • Langerhans cell number is an independent prognostic factor for HNSCC patients. • Langerhans cell number increases in cancer lesions and invaded lymph nodes compared to preneoplastic lesions. • Number of Langerhans cells is decreased in tumors of HPV-positive patients. • Langerhans cell number correlates with MIP-3α expression in HNSCC.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2016.08.016