β-Catenin-Independent Roles of Wnt/LRP6 Signaling

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt...

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Veröffentlicht in:Trends in cell biology 2016-12, Vol.26 (12), p.956-967
Hauptverfasser: Acebron, Sergio P, Niehrs, Christof
Format: Artikel
Sprache:eng
Schlagworte:
Animals
beta Catenin - metabolism
GSK3
Humans
Low Density Lipoprotein Receptor-Related Protein-6 - metabolism
mitosis
Models, Biological
Pathology
post-transcriptional Wnt signaling
Protein Stability
proteolysis
Receptor Cross-Talk
Wnt Signaling Pathway
Wnt/STOP
β-catenin
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Zusammenfassung:Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.07.009