Abstract 947: Polycomb protein SUZ12 is regulated by a novel miRNA like RNA (miR-G655A) present in extracellular vesicles secreted by mesenchymal stemtromal cells

Introduction: Role of human mesenchymal stemstromal cells (hMSCs) in cancer progression is well studied. Previously, we showed that hMSCs use autophagy to survive in adverse environment (e.g. serum deprivation). Using this model to mimic the solid tumor core, we1ve shown that the secretome of these stressed hMSCs is also tumor supportive. Furthermore, we showed that extracellular vesicles (EVs) secreted by cells contain small RNAs, proteins and lipids that are tumor supportive. In this study, we focused on a new and unknown small RNA contained in EVs, its potential mRNA targets in recipient cancer cells and its regulation in parent hMSCs and other cancer cells.