Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction

Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (98), p.14101-14104
Hauptverfasser:	Zheng, Xiao-Hui, Mu, Ge, Zhong, Yi-Fang, Zhang, Tian-Peng, Cao, Qian, Ji, Liang-Nian, Zhao, Yong, Mao, Zong-Wan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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