Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction

Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction

Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (98), p.14101-14104
Hauptverfasser: Zheng, Xiao-Hui, Mu, Ge, Zhong, Yi-Fang, Zhang, Tian-Peng, Cao, Qian, Ji, Liang-Nian, Zhao, Yong, Mao, Zong-Wan
Format: Artikel
Sprache:eng
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Zusammenfassung:Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08254h