Adenosine Producing Mesenchymal Stem Cells

Adenosine Producing Mesenchymal Stem Cells

Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell‐autonomous fashion, other t...

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Veröffentlicht in:Stem cells (Dayton, Ohio) Ohio), 2017-06, Vol.35 (6), p.1647-1648
Hauptverfasser: Schuler, Patrick J., Brandau, Sven
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Adenosine - biosynthesis
Antigens, CD - metabolism
ATP
Head and neck cancer
Humans
Immunology
Lymphocytes T
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mesenchyme
Metabolites
Microenvironment
Skin & tissue grafts
Stem cells
Treg
Tumor
Tumor Microenvironment
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Zusammenfassung:Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell‐autonomous fashion, other types of MSC require the cooperative activity of T‐cells. Stem Cells 2017;35:1647–1648
ISSN:1066-5099
1549-4918
DOI:10.1002/stem.2532