Sec61β – a component of the archaeal protein secretory system

Sec61β – a component of the archaeal protein secretory system

Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI–BLAST, the archaeal count...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2002-04, Vol.27 (4), p.170-171
Hauptverfasser: Kinch, Lisa N., Saier, Jr, Milton H., Grishin, Nick V.
Format: Artikel
Sprache:eng
Schlagworte:
homology prediction
membrane proteins
motif
protein secretory pathway
PSI-BLAST
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Zusammenfassung:Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61α/SecY and Sec61γ/SecE exist in archaea, identification of the third component (Sec61β or SecG) has remained elusive. Using PSI–BLAST, the archaeal counterpart of Sec61β has been detected. With the identification of the Sec61β motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(01)02055-2