Association of BDNF Val66MET Polymorphism With Parkinson’s Disease and Depression and Anxiety Symptoms

An association between Parkinson’s disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects c...

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Veröffentlicht in:	The journal of neuropsychiatry and clinical neurosciences 2017-04, Vol.29 (2), p.142-147
Hauptverfasser:	Cagni, Fernanda Carvalho, Campêlo, Clarissa Loureiro das Chagas, Coimbra, Daniel Gomes, Barbosa, Mayara Rodrigues, Júnior, Luiz Gonzaga Oliveira, Neto, Antônio Braz Silva, Ribeiro, Alessandra Mussi, Júnior, Clécio de Oliveira Godeiro, Gomes de Andrade, Tiago, Silva, Regina Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anxiety - genetics Brain-Derived Neurotrophic Factor - genetics Depression - genetics Disease Progression Female Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype Humans Male Methionine - genetics Middle Aged Parkinson Disease - genetics Polymorphism, Genetic - genetics Valine - genetics
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Zusammenfassung:	An association between Parkinson’s disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.
ISSN:	0895-0172 1545-7222
DOI:	10.1176/appi.neuropsych.16040062