Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts

The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.

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Bibliographische Detailangaben
Veröffentlicht in:	Fitoterapia 2002-02, Vol.73 (1), p.28-31
Hauptverfasser:	Ganapaty, S., Dash, G.K., Subburaju, T., Suresh, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cathartics - administration & dosage Cathartics - pharmacology Cathartics - therapeutic use Cocculus hirsutus Constipation - drug therapy Diarrhea - drug therapy Diuresis - drug effects Diuretic activity Diuretics - administration & dosage Diuretics - pharmacology Diuretics - therapeutic use Dose-Response Relationship, Drug Female Gastrointestinal Motility - drug effects General pharmacology Laxative activity Male Medical sciences Menispermaceae Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Structures Rats Rats, Wistar
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Beschreibung
Zusammenfassung:	The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.
ISSN:	0367-326X
DOI:	10.1016/S0367-326X(01)00345-8