Serum albumin: a risk of stroke?

Serum albumin, as the transporter of hormones, drugs, amino acids, and free fatty acids in the blood and the modulator of the colloid osmotic pressure in blood, can improve blood flow perfusion of brain [3], enhance micrangium perfusion [4], reduce the various cytokines' adhesion within postcapillary microcirculation [5], and increase the transport of free fatty acids postischemia [6]. In the study of Kato et al [7], they considered that the increased risk of TE in patients with proteinuria resulted from urinary loss of antithrombin, lower free protein S levels and reduced protein C activity, and activation of the coagulation system. [...]the urinary loss of vitamin D-binding protein (by lowing serum vitamin D level) and of the albumin-bound calcium accounts might contribute to TE occurrence, as ionized calcium is the coagulation factor IV and has the crucial role in coagulation system [8].