Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice

Highlights • IL-33 is positively involved in wound healing. • IL-33 involvement in wound healing is dependent on nuclear factor kappa B. • Nuclear IL-33, but not IL-33 as a cytokine, is involved in wound healing. • IL-33 involvement in wound healing is also dependent on re-epithelialization process...

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Veröffentlicht in:	Journal of dermatological science 2017-02, Vol.85 (2), p.106-114
Hauptverfasser:	Oshio, Tomoyuki, Ph.D, Komine, Mayumi, M.D. Ph.D, Tsuda, Hidetoshi, Ph.D, Tominaga, Shin-ichi, M.D. Ph.D, Saito, Hirohisa, M.D. Ph.D, Nakae, Susumu, M.D. Ph.D, Ohtsuki, Mamitaro, M.D. Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Dermatology Epidermis - cytology Epidermis - pathology Epithelialization Humans IL-33 Immunohistochemistry Interleukin-1 Receptor-Like 1 Protein - genetics Interleukin-1 Receptor-Like 1 Protein - metabolism Interleukin-33 - genetics Interleukin-33 - metabolism Keratinocytes Keratinocytes - metabolism Macrophages - physiology Male Mice Mice, Inbred BALB C Mice, Knockout Nuclear expression Primary Cell Culture Real-Time Polymerase Chain Reaction Signal Transduction Wound healing Wound Healing - physiology
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Zusammenfassung:	Highlights • IL-33 is positively involved in wound healing. • IL-33 involvement in wound healing is dependent on nuclear factor kappa B. • Nuclear IL-33, but not IL-33 as a cytokine, is involved in wound healing. • IL-33 involvement in wound healing is also dependent on re-epithelialization process of keratinocytes.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.10.008