Design of Bioactive materials for strictly regulating graft cells to cure the central nervous disorders

The therapy using cell transplantation has been focused as the potential method to completely cure intractable disorders. Especially, it has been said that the cell-based therapy is exclusive method to fully recover Parkinson’s disease because the cause of Parkinson’s disease is the denaturation and dropout of dopaminergic neuron in the striatum of the midbrain. From these backgrounds, various researches concerning the cell-based therapy of Parkinson’s disease using brain tissue of the fetus, neural progenitor cells derived from fetus tissue and pluripotent stem cells have been carried out. However, we found that the initial viability of transplanted tissue and cells is extremely low(~5%) and the transplanted cells cannot be received the regulation for regeneration of crushed tissue from the host. Therefore, our group aimed to develop a functional hydrogel for cell transplantation to protect the graft survival and control the grafted cells for neuronal regeneration.