Effect of Kineret registered on ovarian ischemia reperfusion injury in a rat model

Aim To investigate the effect of Kineret registered on ischemia reperfusion (IR) injury in rat ovaries. Methods Rats were divided into four groups: ovarian IR (IRG); 50 mg/kg Kineret registered + ovarian IR (KIR-50); 100 mg/kg Kineret registered + ovarian IR (KIR-100); and sham operation (SOC). KIR-50 (n = 10) and KIR-100 (n = 10) groups received an intraperitoneal injection of Kineret registered at doses of 50 and 100 mg/kg, respectively. IRG and SOC (n = 10) rat groups were given distilled water as solvent using the same method. The results were compared between the groups. Results In rats in which IR occurred, oxidant parameters, such as malondialdehyde (MDA) and myeloperoxidase (MPO), were increased, the level of proinflammatory interleukin 1 beta (IL-1 beta ) was elevated and total glutathione (tGSH) as an antioxidant was decreased in the ovarian tissues. Administration of Kineret registered at a dose of 100 mg/kg inhibited the increase of MDA, MOP and IL-1 beta and a decrease in tGSH caused by IR more significantly than administration of Kineret registered at a dose of 50 mg/kg. In addition, 100 mg/kg Kineret registered significantly decreased severe hemorrhage, degeneration and inflammatory signs in the follicular cells, caused by IR. Kineret registered at 100 mg/kg markedly ameliorated increased apoptosis in ovarian tissue with IR more significantly than 50 mg/kg kineret. Conclusion Our findings indicate that Kineret registered might be useful in clinical practice for the treatment of damage that may occur as a result of ovarian torsion.