An Application of Ultraviolet Spectroscopy to Study Interactions in Proteins Solutions at High Concentrations

Studies of protein–protein interactions (PPIs), especially in high-concentration solutions, have become increasingly important from a pharmaceutical perspective. Analytical methods used to study protein interactions, however, rely primarily on the detection of nonideality in relatively dilute (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2012-09, Vol.101 (9), p.3051-3061
Hauptverfasser:	Thakkar, Santosh V., Allegre, Kevin M., Joshi, Sangeeta B., Volkin, David B., Middaugh, C. Russell
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Antibodies, Monoclonal - chemistry Biological and medical sciences General pharmacology high concentration interaction Light light scattering Medical sciences Models, Chemical Muramidase - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments protein Protein Binding Proteins - chemistry Scattering, Radiation Serum Albumin, Bovine - chemistry Solubility Spectrophotometry, Ultraviolet Technology, Pharmaceutical - methods UV/Vis spectroscopy Viscosity
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Beschreibung
Zusammenfassung:	Studies of protein–protein interactions (PPIs), especially in high-concentration solutions, have become increasingly important from a pharmaceutical perspective. Analytical methods used to study protein interactions, however, rely primarily on the detection of nonideality in relatively dilute (
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.23188