Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical...

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Veröffentlicht in:	European journal of immunology 2016-10, Vol.46 (10), p.2481-2483
Hauptverfasser:	Tietz, Silvia M., Zwahlen, Marcel, Haghayegh Jahromi, Neda, Baden, Pascale, Lazarevic, Ivana, Enzmann, Gaby, Engelhardt, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area under the curve Bland‐Altman plots Clinical scoring Disease Models, Animal Disease Progression Encephalomyelitis, Autoimmune, Experimental - diagnosis Experimental autoimmune encephalomyelitis Humans Mice Mice, Inbred C57BL Mice, Knockout Multiple Sclerosis - diagnosis Observer Variation Research Design Rodents Severity of Illness Index Statistical analysis
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Zusammenfassung:	Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.201546272