The effects of short-term overfeeding on energy expenditure and nutrient oxidation in obesity-prone and obesity-resistant individuals

Objective: The roles that energy expenditure (EE) and nutrient oxidation play in a predisposition for weight gain in humans remains unclear. Subjects: We measured EE and respiratory exchange ratio (RER) in non-obese obesity-prone (OP; n =22) and obesity-resistant (OR; n =30) men and women following a eucaloric (EU) diet and after 3 days of overfeeding (1.4 × basal energy). Results: Twenty-four hour EE, adjusted for fat-free mass and sex, measured while consuming a EU diet was not different between OP and OR subjects (2367±80 vs 2285±98 kcals; P =0.53). Following overfeeding, EE increased in both OP and OR (OP: 2506±63.7, P