The impact of l -dopa on attentional impairments in a rat model of Parkinson’s disease

Highlights • l -Dopa dose necessary to recover motor function can also successfully restore disengagement behavior in the short term. • l -Dopa dose that recovers disengagement behavior and motor function does not improve selective and sustained attention. • l -Dopa therapy may not be sufficient for...

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Veröffentlicht in:	Neuroscience 2016-11, Vol.337, p.295-305
Hauptverfasser:	Smith, Elizabeth S, Hardy, Gwendolyn A, Schallert, Timothy, Lee, Hongjoo J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - pharmacology Attention - drug effects Behavior, Animal - drug effects Corpus Striatum - drug effects Disease Models, Animal disengagement behavior Dopamine - pharmacology Dyskinesia, Drug-Induced - drug therapy l-dopa Levodopa - pharmacology Male Medial Forebrain Bundle - drug effects Motor Activity - drug effects Neurology Oxidopamine - pharmacology Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson’s disease Rats, Sprague-Dawley selective and sustained attention
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Zusammenfassung:	Highlights • l -Dopa dose necessary to recover motor function can also successfully restore disengagement behavior in the short term. • l -Dopa dose that recovers disengagement behavior and motor function does not improve selective and sustained attention. • l -Dopa therapy may not be sufficient for treating all types of attentional dysfunction occurring in Parkinson’s disease.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.09.022