Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells

Paper Highlights • Tyrosine kinase inhibitors lapatinib and neratinib show opposite effects on ErbB2 levels • Both lapatinib and neratinib treatment elevates ErbB2 mRNA • Neratinib induces more potent endocytic degradation via endolysosome system than lapatinib • Neratinib triggers ErbB2 ubiquitylat...

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Veröffentlicht in:	Cancer letters 2016-11, Vol.382 (2), p.176-185
Hauptverfasser:	Zhang, Yingqiu, Zhang, Jinrui, Liu, Congcong, Du, Sha, Feng, Lu, Luan, Xuelin, Zhang, Yayun, Shi, Yulin, Wang, Taishu, Wu, Yue, Cheng, Wei, Meng, Songshu, Li, Man, Liu, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell cycle Cell Line, Tumor Conflicts of interest Endocytosis Endocytosis - drug effects ErbB2 Experiments Female Hematology, Oncology and Palliative Medicine HER2 HSP90 Heat-Shock Proteins - metabolism Humans Immunoglobulins Kinases Lysosomes - drug effects Lysosomes - metabolism Microscopy Mutation Neratinib Phosphatase Protein Binding Protein Kinase Inhibitors - pharmacology Proteins Proteolysis Quinolines - pharmacology Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Signal transduction Time Factors Transfection Ubiquitination - drug effects Ubiquitylation
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Zusammenfassung:	Paper Highlights • Tyrosine kinase inhibitors lapatinib and neratinib show opposite effects on ErbB2 levels • Both lapatinib and neratinib treatment elevates ErbB2 mRNA • Neratinib induces more potent endocytic degradation via endolysosome system than lapatinib • Neratinib triggers ErbB2 ubiquitylation through HSP90 dissociation
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.08.026