Increased susceptibility of G-protein-coupled receptor 6 deficient mice to MPTP neurotoxicity

Highlights • GPR6 deficiency increases striatal tissue concentration of dopamine in mice. • MPTP toxicity (i.e. striatal dopamine depletion, degeneration of nigral TH-positive neurons) is increased in GPR6−/− -mice. • GPR 6 deficiency in mice increases MPP+ -induced dopamine release in the striatum....

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Veröffentlicht in:	Neuroscience 2016-11, Vol.337, p.218-223
Hauptverfasser:	Oeckl, Patrick, Ferger, Boris
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Corpus Striatum - drug effects Corpus Striatum - metabolism dopamine Dopamine - pharmacology GPR6 in vivo microdialysis Mice, Transgenic MPTP MPTP Poisoning - metabolism Neostriatum - drug effects Neostriatum - metabolism Neurology Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Parkinson Disease - drug therapy Parkinson’s disease Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - metabolism striatum Substantia Nigra - drug effects Substantia Nigra - metabolism
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Zusammenfassung:	Highlights • GPR6 deficiency increases striatal tissue concentration of dopamine in mice. • MPTP toxicity (i.e. striatal dopamine depletion, degeneration of nigral TH-positive neurons) is increased in GPR6−/− -mice. • GPR 6 deficiency in mice increases MPP+ -induced dopamine release in the striatum.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.09.021