Glutamate release inhibitor, Riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production

Highlights • Riluzole leads to a suppression of cell proliferation in liver cancer cells. • Riluzole induced caspase-dependent apoptosis and G2/M cell cycle arrest. • Riluzole-treated cells have increased level of inner cellular glutamate • Riluzole-treated cells have decrease the glutathione (GSH)...

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Veröffentlicht in:	Cancer letters 2016-11, Vol.382 (2), p.157-165
Hauptverfasser:	Seol, Hyang Sook, Lee, Sang Eun, Song, Joon Seon, Lee, Hye Yong, Park, Sojung, Kim, Inki, Singh, Shree Ram, Chang, Suhwan, Jang, Se Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell cycle Cell Cycle Proteins - metabolism Cell growth Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Repositioning Excitatory Amino Acid Antagonists - pharmacology G2 Phase Cell Cycle Checkpoints - drug effects Glutamic Acid - metabolism Glutathione - metabolism Growth factors Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Humans Kinases Laboratories Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice, Inbred NOD Mice, Nude Mice, SCID Oxidative Stress - drug effects Patients Reactive Oxygen Species - metabolism Riluzole Riluzole - pharmacology ROS Signal Transduction - drug effects Tumor Burden - drug effects Tumor Cells, Cultured Tumors Up-Regulation Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Highlights • Riluzole leads to a suppression of cell proliferation in liver cancer cells. • Riluzole induced caspase-dependent apoptosis and G2/M cell cycle arrest. • Riluzole-treated cells have increased level of inner cellular glutamate • Riluzole-treated cells have decrease the glutathione (GSH) level and increase reactive oxygen species (ROS) production. • Riluzole-induced GSH and ROS changes in a Huh7 xenograft cancer model.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.08.028