Prognosis and survival analysis of paraquat poisoned patients based on improved HPLC-UV method

Paraquat (PQ) has caused deaths of numerous people around the world. In order to assess the lethal plasma concentration, the patients who acquired acute PQ intoxication were analyzed by plasma concentration monitoring. The plasma PQ concentrations were determined by high performance liquid chromatog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmacological and toxicological methods 2016-07, Vol.80, p.75-81
Hauptverfasser:	Hong, Guangliang, Hu, Lufeng, Tang, Yahui, Zhang, Tao, Kang, Xiaowen, Zhao, Guangju, Lu, Zhongqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Blood Coagulation - drug effects Calibration Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Female Hemoperfusion Herbicides - blood Herbicides - poisoning HPLC Humans Kidney Function Tests Length of Stay Liver Function Tests Male Middle Aged Paraquat Paraquat - blood Paraquat - poisoning Patient Prognosis Reproducibility of Results Spectrophotometry, Ultraviolet Survival Analysis Treatment Outcome Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Paraquat (PQ) has caused deaths of numerous people around the world. In order to assess the lethal plasma concentration, the patients who acquired acute PQ intoxication were analyzed by plasma concentration monitoring. The plasma PQ concentrations were determined by high performance liquid chromatography (HPLC) which used 5-bromopyrimidine as internal standard and trichloroacetic acid-methanol (1:9) as protein precipitant. The liver, kidney and coagulation function were determined by automatic biochemical analyzer. According to plasma PQ concentration, 90 patients were divided into four groups: trace PQ group (
ISSN:	1056-8719 1873-488X
DOI:	10.1016/j.vascn.2016.05.010